The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...) research. PRO (http://pir.georgetown.edu/pro) is part of the Open Biomedical Ontologies (OBO) Foundry. (shrink)

The Protein Ontology (PRO) web resource provides an integrative framework for protein-centric exploration and enables specific and precise annotation of proteins and protein complexes based on PRO. Functionalities include: browsing, searching and retrieving, terms, displaying selected terms in OBO or OWL format, and supporting URIs. In addition, the PRO website offers multiple ways for the user to request, submit, or modify terms and/or annotation. We will demonstrate the use of these tools for protein research and annotation.

Biomedical ontologies are emerging as critical tools in genomic and proteomic research where complex data in disparate resources need to be integrated. A number of ontologies exist that describe the properties that can be attributed to proteins; for example, protein functions are described by Gene Ontology, while human diseases are described by Disease Ontology. There is, however, a gap in the current set of ontologies—one that describes the protein entities themselves and their relationships. We have designed a PRotein Ontology (PRO) (...) to facilitate protein annotation and to guide new experiments. The components of PRO extend from the classification of proteins on the basis of evolutionary relationships to the representation of the multiple protein forms of a gene (products generated by genetic variation, alternative splicing, proteolytic cleavage, and other post-translational modification). PRO will allow the specification of relationships between PRO, GO and other OBO Foundry ontologies. Here we describe the initial development of PRO, illustrated using human proteins from the TGF-beta signaling pathway. (shrink)

Researchers and practitioners are increasingly using machine‐generated synthetic data as a tool for advancing health science and practice, by expanding access to health data while—potentially—mitigating privacy and related ethical concerns around data sharing. While using synthetic data in this way holds promise, we argue that it also raises significant ethical, legal, and policy concerns, including persistent privacy and security problems, accuracy and reliability issues, worries about fairness and bias, and new regulatory challenges. The virtue of synthetic data is often understood (...) to be its detachment from the data subjects whose measurement data is used to generate it. However, we argue that addressing the ethical issues synthetic data raises might require bringing data subjects back into the picture, finding ways that researchers and data subjects can be more meaningfully engaged in the construction and evaluation of datasets and in the creation of institutional safeguards that promote responsible use. (shrink)

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification (...) reference. We illustrate its use in facilitating an alignment between PRO and Reactome protein entities. We also address issues of scalability, describing our first steps into the use of text mining to identify protein-related entities, the large-scale import of proteoform information from expert curated resources, and our ability to dynamically generate PRO terms. Web views for individual terms are now more informative about closely-related terms, including for example an interactive multiple sequence alignment. Finally, we describe recent improvement in semantic utility, with PRO now represented in OWL and as a SPARQL endpoint. These developments will further support the anticipated growth of PRO and facilitate discoverability of and allow aggregation of data relating to protein entities. (shrink)

La précarité fait référence à l'existence de la rareté. Judith Butler montre l'impossibilité d'être un à travers le concept hégélien du sujet heureux. Le sujet ainsi défini est projeté sur l'Autre – langage, normes sociales, regard extérieur –, ce qui conduit à un état de vulnérabilité : je dépends de ce que je ne serai pas. Cependant, l'impuissance, loin d'être parfaite, peut se transformer en puissance sans s'affranchir des frontières qui la définissent, si elle défie les illusions modernes de (...) la sensualité et permet la présence et l'origine de la coexistence. De même, loin d'être la fin de l'éthique, celle-ci est différente pour chaque acteur du monde dans lequel il vit. (shrink)

Judith Butler argues for collective liberatory action grounded in ontological vulnerability. Yet descriptive social ontology alone provides neither normative ethical prescriptions nor direction for political action. I believe Butler tries to overcome this gap by appealing to equality as an ethical ideal. In this article, I reconstruct how equality operates in her transition from ontological vulnerability to prescriptive commitments. Then, turning to Sylvia Wynter, I argue Butler's uncritical use of equality constrains the radical direction of her liberatory goals—firstly because (...) it cannot mitigate the coloniality of Being, and secondly because she figures the locus of critique as an anonymous and equally vulnerable body at the limits of the recognizably human. I conclude with Wynter's demand for liberatory critique to arise out of specific decolonial locations of rupture from our historically situated, oppressive, and overrepresented genre of being human. (shrink)

The ‘liberal-communitarian’ debate arose within anglophone political philosophy during the 1980s. This essay opens with an account of the main outlines of the debate, showing how liberals and communitarians tended to confront each other with opposing interpretations of John Rawls’ Theory of Justice (1999; originally published in 1971) and Political Liberalism (2005; originally published in 1993). The essay then proceeds to discuss four forms of ‘liberalism after communitarianism’: Michael Freeden’s account of liberalism as an ideology; Joseph Raz and Will Kymlicka’s (...) perfectionist liberalisms; the liberalism of value pluralists such as Isaiah Berlin and Bernard Williams; and Judith N. Shklar’s liberalism of fear. It concludes with the suggestion that there are times when liberals of every kind should set aside their ideology, even if only temporarily, in order to listen to their interlocutors with truly open minds. (shrink)

The article provides an account of the unlikely revival of the medieval Just War Theory, due in large part to the efforts of Michael Walzer. Its purpose is to address the question: What is a just war theorist? By exploring contrasts between scholarly activity and forms of international activism, the paper argues that just war theorists appear to be just war criminals, both on the count of aiding and abetting aggression and on the count of inciting troops to commit war (...) crimes. (shrink)

DA: I anledning af Judith Butlers forelæsning om klimasorg på KU er jeg blevet bedt om at besvare spørgsmålet om, hvad man kan bruge Butlers tænkning til i dag og om den stadig er aktuel. Min første tanke var at besvare spørgsmålet med svaret: Man kan bruge Butlers tænkning til ALT! Men for at fokusere mit svar, har jeg besluttet mig for at gennemgå Butlers tænkning i forhold til spørgsmålet om prekære liv og vold og ikke-vold, og hvordan disse (...) emner udspringer af Butlers tænkning om køn i 1990’erne. -/- EN: In connection with Judith Butler's lecture on climate grief at KU, I have been asked to answer the question of how Butler's thinking could be used today and whether it is still relevant. My first thought was to answer the question with the answer: You can use Butler's thinking for EVERYTHING! However, to focus my answer, I have decided to review Butler's thinking in relation to the issues of precarious lives and violence and non-violence and how these issues stem from Butler's thinking on gender in the 1990s. (shrink)

We live in the age of postmodernism. What does that mean? With a call for essays, we asked for proposals for a better understanding. At the same time, we were looking for posts that show how the arts have processed and are still processing the change from the modern to the postmodern selfconception of man, which has been described by philosophy since the 1950s to today. This special issue thus demonstrates how architects, designers and artists have reacted to the new (...) socio-politically relevant concepts of postmodernism. -/- With contributions of Simone Kraft on architecture, Arianna Fantuzzi on self-portraits, Stephan Schmidt-Wulffen on visual arts in the 1980s, Anna Kristensson on design, Iris Laner on postmodern theory and the work of Jeff Wall, Christiane Wagner on postmodern avatars and finally, I contributed with a text on the deconstruction of the familiar in postmodern theory and the work of Karin Kneffel. (shrink)

FISIOLOGIA DA REPRODUÇÃO BOVINA: 2 - ESTRO E SERVIÇO -/- -/- INTRODUÇÃO -/- -/- A identificação de vacas em cio (estro ou cio) é, sem dúvida, a prática mais importante no manejo da reprodução do rebanho leiteiro. Apesar dos avanços no conhecimento da fisiologia da reprodução a nível celular e molecular, a identificação de vacas em estro continua sendo o problema reprodutivo mais importante e o que mais causa prejuízos econômicos. Na indústria de laticínios no Brasil, seu impacto não foi (...) estimado, porém, a estimativa feita por países como os Estados Unidos onde se perdem 300 milhões de dólares por ano pode dar uma ideia, atribuída apenas à baixa eficiência na detecção de estros. Por que é cada vez mais difícil detectar vacas em estro? A resposta está relacionada aos aspectos intrínsecos da vaca leiteira moderna, associadas as práticas de manejo dos rebanhos atuais, caracterizados por possuírem grande número de vacas nos plantéis. -/- -/- 2.1 Como saber que uma vaca está em cio/estro? -/- -/- O comportamento estral é causado por um aumento no estradiol sérico produzido pelo folículo ovulatório. O aumento do estradiol provoca mudanças de comportamento e modificações na genitália externa e interna. A vaca mostra-se inquieta, sua vocalização aumenta, ela anda mais, tenta montar em outras vacas e aceita montar no touro ou em outra vaca, bem como urinam com mais frequência (micção frequente). A vulva fica levemente inflamada, à palpação retal o útero pode ser visto com tônus ou turgor (duro e contraído) e ao massagear o colo do útero observa-se que sai abundante muco cristalino da vulva. O mecanismo clássico proposto na regulação do estro é baseado principalmente no papel do estradiol; no entanto, estudos recentes indicam que o GnRH pode participar da regulação do estro ao nível do hipotálamo. O estro possui duração entre 8 e 18 horas e a intensidade do mesmo é afetada por fatores ambientais e intrínsecos a vaca moderna (figuras de 1 a 6). -/- -/- -/- Figura 2: A observação do grupo sexualmente ativo facilita a identificação das vacas em estro. -/- Figura 1: As vacas em estro formam grupos ativos (grupo sexualmente ativo) separados do resto das vacas. A conformação desses grupos facilita a observação do estro. -/- -/- A formação de grupos de vacas é um fator ideal para a detecção de vacas em cio, elas ficam juntas e começam a montar uma nas outras, a cheirar a urina de ambas etc. comportamentos que podem ser visualizados de longe pelo tratador e diagnosticado o cio o mais breve possível para o manejo reprodutivo adotado pela propriedade seja para monta natural ou controlada e/ou inseminações artificiais (IA) e artificiais em tempo fixo (IATF). -/- -/- Figura 3: O único comportamento positivo do estro é a aceitação da monta de outra vaca. É frequente que a vaca que realiza a monta também esteja em estro, o que só será afirmado até que ela aceite a monta de outra vaca. -/- -/- Figura 4: Cada monta dura de 5 a 7 segundos -/- Figura 5: A vaca leiteira aceita de 5 a 30 montas distribuídas entre 8 e 18 horas. -/- Figura 6: Além das mudanças comportamentais, os estrogênios causam alterações na genitália interna. Uma delas é a produção de muco cervical, que juntamente com o turgor uterino, constituem os sinais genitais do estro. -/- -/- O cio pode ser dividido em três fases, a inicial, a fase de cio verdadeiro e a fase final. O cio verdadeiro quando é observado, é caracterizado pelo momento em que a vaca aceita claramente a monta. Por sua vez, os sinais de início e final de cio se misturam, apresentam nervosismo e inquietação, cheiram e lambem a vagina e a urina de outras vacas, apoiam a cabeça na garupa de outras fêmeas etc. (figura 7). Uma das sugestões adotadas nas propriedades para facilitar a identificação do cio em um rebanho é realizada pelos funcionários com a utilização de um bastão ou fita de coloração da garupa das vacas. -/- Figura 7: Principais sinais que demonstram que a vaca está entrando em cio. As imagens mostram o início do cio, cio verdadeiro e final do cio. -/- CONTINUA. BAIXE O PDF!!! -/- RESUMO -/- -/- < >Nos Estados Unidos, 300 milhões de dólares são perdidos devido à baixa eficiência na detecção do estro. A eficiência na detecção do estro no Brasil é de 40 a 50%. A meta de eficiência para detecção de estro é > 60%. Com a observação das vacas em dois períodos diários de três horas cada (manhã e tarde), consegue-se uma eficiência na detecção de estro de 80%. Menos de 20 por cento das vacas devem ter um intervalo de serviço duplo e nenhum de mais de 48 dias. A taxa de prenhez é obtida multiplicando-se a eficiência na detecção do estro pela porcentagem de concepção e dividindo por 100 (50 * 30/100 = 15%). A taxa de prenhez em rebanhos norte-americanos é de 15%. Nos Estados Unidos, para cada ponto percentual que diminui a taxa de prenhez, não há mais de US$ 12 a US$ 15 por vaca por ano. No Brasil, para cada ponto percentual que aumenta a taxa de prenhez, na faixa de 15 a 20%, é gerada uma renda anual adicional de $ 190 reais por vaca. Não mais que 25% das vacas devem estar vazias no 150º dia pós-parto. Não mais do que 8% devem as vacas ser cobertas no 250º dia pós-parto. 8% das vacas devem engravidar a cada mês. O estro ocorre 48 a 120 horas após o tratamento com PGF2α. 80% é a precisão na palpação do corpo lúteo. Quatorze dias devem decorrer entre duas injeções de PGF2α. Menos de 25% das vacas incluídas no programa de pré-sincronização devem chegar à IATF. No momento da ovulação, a primeira injeção de GnRH deve ser aplicada entre o quinto e o nono dia do ciclo estral. A inseminação cronometrada é realizada 14-16 horas após a segunda injeção de GnRH. O tratamento com dispositivos intravaginais liberadores de progesterona dura 12 dias. Se a duração do tratamento é menor deve-se injetar PGF2α ao retirá-lo. -/- -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- -/- ATUESTA, Jorge; DIAZA, Angela Gonella. Control hormonal del ciclo estral en bovinos y ovinos. Spei Domus, v. 7, n. 14, 2011. -/- COLAZO, Marcos Germán; MAPLETOFT, Reben. Fisiología del ciclo estral bovino. Ciencia Veterinaria, v. 16, n. 2, p. 31-46, 2017. -/- Fisiologia Clínica do Ciclo Estral de Vacas Leiteiras: Desenvolvimento Folicular, Corpo Lúteo e Etapas do Estro. Belo Jardim: IFPE, 2020. -/- Fisiologia da Reprodução Animal: Ovulação, Controle e Sincronização do Cio. Belo Jardim: IFPE, 2020. -/- DOBSON, H. et al. The high‐producing dairy cow and its reproductive performance. Reproduction in domestic animals, v. 42, p. 17-23, 2007. -/- DO VALLE, Ezequlel Rodrigues. O ciclo estral de bovinos e métodos de controle. EMBRAPA-CNPGC., 1991. -/- FURTADO, Diego Augusto et al. Inseminação artificial em tempo fixo em bovinos de corte. Revista científica eletrônica de medicina veterinária, v. 16, p. 1-25, 2011. -/- GALON, Nadav. The use of pedometry for estrus detection in dairy cows in Israel. Journal of Reproduction and Development, v. 56, n. S, p. S48-S52, 2010. -/- HOPPER, Richard M. (Ed.). Bovine reproduction. John Wiley & Sons, 2014. -/- LOPEZ, H.; SATTER, L. D.; WILTBANK, M. C. Relationship between level of milk production and estrous behavior of lactating dairy cows. Animal reproduction science, v. 81, n. 3-4, p. 209-223, 2004. -/- MACMILLAN, Keith L. Recent advances in the synchronization of estrus and ovulation in dairy cows. Journal of Reproduction and development, v. 56, n. S, p. S42-S47, 2010. -/- MUNIS DE OLIVEIRA, G. Fisiologia da Reprodução Bovina e Métodos de Controle do Ciclo Estral. Trabalho de conclusão do curso de especialização em Reprodução e Produção de Bovinos–UCB. Rio de Janeiro, Brasil, 2006. -/- O'CONNOR, MICHAEL L. Estrus detection. In: Current therapy in large animal theriogenology. WB Saunders, 2007. p. 270-278. -/- RIPPE, Christian A. El ciclo estral. In: Dairy Cattle Reproduction Conference. 2009. p. 111-116. -/- ROELOFS, Judith et al. When is a cow in estrus? Clinical and practical aspects. Theriogenology, v. 74, n. 3, p. 327-344, 2010. -/- VIVEIROS, Ana Tereza de Mendonça. Fisiologia da reprodução de bovinos. Lavras: UFLA, p. 62, 1997. (shrink)

Text and notebooks by Friedrich Nietzsche. -/- Translations: -/- 15 = U II 11 Spring 1876? [1-27] pages 13-19 16 = N II 1. 1876. [1-55] pages 20-29 17 = U II 5b. Summer 1876. [1-105] pages 30-48 18 = M I 1. September 1876. [1-62] pages 49-62 19 = U II 5c. October-December 1876. [1-120] pages 63-87 20 = Mp = XIV 1a (Brenner). Winter 1876-1877. [1-21] pages 88-94 21 = N II 3 End of 1876 - Summer 1877. (...) [1-84] pages 95-106 Nietzsche’s Notebooks in English: a Translator’s Introduction and Afterward pages 107-118 Also include two early essays: About Truth and lie in the extra-moral sense. ……………pages 119-128 About the pathos of truth. Christmas 1872. From: Five prefaces to five unwritten books…….………………..pages 129-133 . (shrink)

Il s’agit d’un excellent examen des interactions génétiques / environnement sur le comportement et, en dépit d’être un peu daté, est une lecture facile et utile. Ils commencent par des études jumelles qui montrent l’impact écrasant de la génétique sur le comportement. Ils notent les études de plus en plus connues de Judith Harris qui étendent et résument les faits que l’environnement familial partagé n’a presque aucun effet sur le comportement et que les enfants adoptés grandissent pour être aussi (...) différents de leurs demi-frères et soeurs que les personnes choisies au hasard. Un point fondamental qu’ils (et presque tous ceux qui discutent de la génétique comportementale) ne parviennent pas à noter est que les centaines (des milliers selon votre point de vue) des universels comportementaux humains, y compris toutes les bases de nos personnalités, sont 100% déterminés par nos gènes, sans aucune variation dans les normales. Tout le monde voit un arbre comme un arbre et non une pierre, cherche et mange de la nourriture, se met en colère et jaloux, etc. Donc, ce dont ils parlent surtout ici, c’est de la quantité d’environnement (culture) qui peut influer sur la mesure dans laquelle les divers traits sont montrés, plutôt que leur apparence. Enfin, ils discutent de l’eugénisme de la manière politiquement correcte habituelle, à défaut de noter que nous et tous les organismes sommes les produits de l’eugénisme de la nature et que les tentatives de vaincre la sélection naturelle avec la médecine, l’agriculture, et la civilisation dans son ensemble, sont désastreuses pour toute société qui persiste à le faire. Jusqu’à 50% de toutes les conceptions, soit environ 100 millions par an, se terminent par un avortement spontané précoce, presque tous sans que la mère soit au courant. Cet abattage naturel de gènes défectueux stimule l’évolution, nous maintient relativement génétiquement sains et rend la société possible. Dysgenics est suffisant pour détruire la civilisation, mais la surpopulation sera do ild’abord. Ceux qui souhaitent un cadre complet à jour pour le comportement humain de la vue moderne de deuxemssyst peuvent consulter mon livre 'The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein et John Searle' 2nd ed (2019). Ceux qui s’intéressent à plus de mes écrits peuvent voir «Talking Monkeys --Philosophie, Psychologie, Science, Religion et Politique sur une planète condamnée --Articles et revues 2006-2017' 3rd ed (2019) et autres. (shrink)

In this paper, the relationship between the e-value of a complex hypothesis, H, and those of its constituent elementary hypotheses, Hj, j = 1… k, is analyzed, in the independent setup. The e-value of a hypothesis H, ev, is a Bayesian epistemic, credibility or truth value defined under the Full Bayesian Significance Testing mathematical apparatus. The questions addressed concern the important issue of how the truth value of H, and the truth function of the corresponding FBST structure M, relate to (...) the truth values of its elementary constituents, Hj, and to the truth functions of their corresponding FBST structures Mj, respectively. (shrink)

Taking his critique of totalitarianizing conceptions of community as a starting point, this text examines Jean-Luc Nancy's work of an ‘ontology of plural singular being’ for its political implications. It argues that while at first this ontology seems to advocate a negative or an anti-politics only, it can also be read as a ‘theory of communicative praxis’ that suggests a certain ethos – in the form of a certain use of symbols (which is expressed only inaptly by the word ‘style’) (...) that would render the ontological plurality of singulars perceptible and practically effective. Finally, some recent texts by Nancy even sidestep the ontology of being-with and face the question of what politics, faced with demands of justice, could be and what a democratic politics could provide. Both of these aspects in Nancy's work, however, still remain to be spelled out more politically. (shrink)

Philosophical treatments of natural kinds are embedded in two distinct projects. I call these the philosophy of science approach and the philosophy of language approach. Each is characterized by its own set of philosophical questions, concerns, and assumptions. The kinds studied in the philosophy of science approach are projectible categories that can ground inductive inferences and scientific explanation. The kinds studied in the philosophy of language approach are the referential objects of a special linguistic category—natural kind terms—thought to refer directly. (...) Philosophers may hope for a unified account addresses both sets of concerns. This paper argues that this cannot be done successfully. No single account can satisfy both the semantic objectives of the philosophy of language approach and the explanatory projects of the philosophy of science approach. After analyzing where the tensions arise, I make recommendations about assumptions and projects that are best abandoned, those that should be retained, and those that should go their separate ways. I also recommend adopting the disambiguating terminology of “scientific kinds” and “natural kinds” for the different notions of kinds developed in these different approaches. (shrink)

This paper analyses the opposing accounts of ‘the ordinary’ given by Jacques Derrida and Stanley Cavell, beginning with their competing interpretations of J. L. Austin¹s thought on ordinary language. These accounts are presented as mutually critiquing: Derrida¹s deconstructive method poses an effective challenge to Cavell¹s claim that the ordinary is irreducible by further philosophical analysis, while, conversely, Cavell¹s valorisation of the human draws attention to a residual humanity in Derrida¹s text which Derrida cannot account for. The two philosophers’ approaches are, (...) in fact, predicated on each other like the famous Gestalt-image of a vase and two faces: they cannot come into focus at the same time, but one cannot appear without the other to furnish its background. (shrink)

This paper explains the metaphysical implications of the view that species are individuals (SAI). I first clarify SAI in light of the separate distinctions between individuals and classes, particulars and universals, and abstract and concrete things. I then show why the standard arguments given in defense of SAI are not compelling. Nonetheless, the ontological status of species is linked to the traditional "species problem," in that certain species concepts do entail that species are individuals. I develop the idea that species (...) names are rigid designators and show how this provides additional motivation for SAI. (shrink)

This paper presents and defends an account of the coincidence of biological organisms with mereological sums of their material components. That is, an organism and the sum of its material components are distinct material objects existing in the same place at the same time. Instead of relying on historical or modal differences to show how such coincident entities are distinct, this paper argues that there is a class of physiological properties of biological organisms that their coincident mereological sums do not (...) have. The account answers some of the most pressing objections to coincidence, for example the so-called grounding problem , that material coincidence seems to require that coinciding objects have modal differences that do not supervene on any other properties. (shrink)

A discussion of the ethics of stem cell research, and attempts to regulate it.

Thought experiments that concoct bizarre possible world modalities are standard fare in debates on personal identity. Appealing to intuitions raised by such evocations is often taken to settle differences between conflicting theoretical views that, albeit, have practical implications for ethical controversies of personal identity in health care. Employing thought experiments that way is inadequate, I argue, since personhood is intrinsically linked to constraining facts about the actual world. I defend a moderate modal skepticism according to which intuiting across conceptually incongruent (...) worlds constitutes ‘invalid intuitioninferences’—i.e., carrying over intuitions gathered from facts about possible worlds that are at odds with facts about the actual world, for the purpose of making claims about real-life persons and their identity, leads to conceptual incongruences. Such a methodological fallout precludes accurate, informative judgments about personal identity in the actual world, calling into question the adequacy of thought experimental considerations for potential real world applications in medical ethics. (shrink)

Locke is often cited as a precursor to contemporary natural kind realism. However, careful attention to Locke’s arguments show that he was unequivocally a conventionalist about natural kinds. To the extent that contemporary natural kind realists see themselves as following Locke, they misunderstand what he was trying to do. Locke argues that natural kinds require either dubious metaphysical commitments (e.g., to substantial forms or universals), or a question-begging version of essentialism. Contemporary natural kind realists face a similar dilemma, and should (...) not appeal to Locke in their defense. (shrink)

This chapter defends a pluralist understanding of species on which a normative species concept is viable and can support natural goodness evaluations. The central question here is thus: Since organisms are to be evaluated as members of their species, how does a proper understanding of species affect the feasibility of natural goodness evaluations? Philippa Foot has argued for a form of natural goodness evaluation in which living things are evaluated by how well fitted they are for flourishing as members of (...) their species, in ways characteristic of their species. She has further argued that assessments of moral goodness in humans are of the same evaluative form. However, natural goodness evaluations and, by extension, the natural goodness approach, do not garner justification in virtue of employing a scientifically privileged conception of species. The natural goodness approach is only justified given particular metaethical and normative commitments that are independent of naturalism, since the approach does not depend upon naturalism alone. (shrink)

Philosophical arguments regarding academic freedom can sometimes appear removed from the real conflicts playing out in contemporary universities. This paper focusses on a set of issues at the front line of these conflicts, namely, questions regarding sex, gender and gender identity. We document the ways in which the work of academics has been affected by political activism around these questions and, drawing on our respective disciplinary expertise as a sociologist and a philosopher, elucidate the costs of curtailing discussion on fundamental (...) demographic and conceptual categories. We discuss some philosophical work that addresses the conceptual distinction between academic freedom and free speech and explore how these notions are intertwined in significant ways in universities. Our discussion elucidates and emphasises the educational costs of curtailing academic freedom. (shrink)

The UK Government's Higher Education (Freedom of Speech) Bill is currently progressing through Parliament. The bill is designed to strengthen free speech and academic freedom in higher education, in response to what former Education Secretary Gavin Williamson describes as ‘the rise of intolerance and cancel culture upon our campuses’. But is there really a crisis of academic freedom in British universities?To see that there is, say Judith Suissa and Alice Sullivan, we need only look at the contemporary reality of (...) suppression of debate on sex and gender. The evidence they catalogue of suppression of research, of blacklisting, harassment and smear campaigns, of no-platforming, disinvitations and shutting down of events, is incontrovertible. The recent experience of scholars and students wishing to discuss the material reality and political salience of sex makes complacency about academic freedom a luxury we cannot afford.Suissa and Sullivan set out a powerful argument for the role of academic freedom in pursuing truth within the academy and developing democracy beyond it. They effectively counter attempts to narrow the scope of academic freedom so as to render it compatible with no-platforming. And they lay out a series of practical steps administrators can take to ensure that universities are places where an expansive and pluralistic intellectual climate prevails.This is a timely and compelling intervention in a vexed but urgent public debate. For their clear-sighted diagnosis of where and how academic freedom has been eroded in our universities, and for their judicious account of what must be done to rebuild it, Suissa and Sullivan deserve a wide and attentive hearing. (shrink)

We examine the proof-theoretic verificationist justification procedure proposed by Dummett. After some scrutiny, two distinct interpretations with respect to bases are advanced: the independent and the dependent interpretation. We argue that both are unacceptable as a semantics for propositional intuitionistic logic.

In Ethics 1p5, Spinoza asserts that “In Nature there cannot be two or more substances of the same nature or attribute”. This claim serves as a crucial premise in Spinoza’s argument for substance monism, yet Spinoza’s demonstration of the 1p5 claim is surprisingly brief and appears to have obvious difficulties. This paper answers the principle difficulties that have been raised in response to Spinoza’s argument for 1p5. The key to understanding the 1p5 argument lies in a proper understanding of the (...) substance-attribute relationship and the principles of metaphysical individuation that Spinoza accepts. (shrink)

: New genetic technologies continue to emerge that allow us to control the genetic endowment of future children. Increasingly the claim is made that it is morally "irresponsible" for parents to fail to use such technologies when they know their possible children are at risk for a serious genetic disorder. We believe such charges are often unwarranted. Our goal in this article is to offer a careful conceptual analysis of the language of irresponsibility in an effort to encourage more care (...) in its use. Two of our more important sub-claims are: A fair judgment of genetic irresponsibility necessarily requires a thick background description of the specific reproductive choice; and there is no necessary connection between an act's being morally wrong and its being irresponsible. These are distinct judgments requiring distinct justifications. (shrink)

Tradução do artigo "What is Critique? An Essay on Foucault's Virtue.".

Bioethicists appearing in the media have been accused of "shooting from the hip" (Rachels, 1991). The criticism is sometimes justified. We identify some reasons our interactions with the press can have bad results and suggest remedies. In particular we describe a target (fostering better public dialogue), obstacles to hitting the target (such as intrinsic and accidental defects in our knowledge) and suggest some practical ways to surmont those obstacles (including seeking out ways to write or speak at length, rather than (...) in sound bites). We make use of our own research into the way journalists quote bioethicists. We end by suggesting that the profession as a whole look into this question more fully. (shrink)

Religious faith may manifest itself, among other things, as a mode of seeing the ordinary world, which invests that world imaginatively (or inspiredly) with an unseen depth of divine intention and spiritual significance. While such seeing may well be truthful, it is also unavoidably constructive, involving the imagination in its philosophical sense of the capacity to organize underdetermined or ambiguous sense date into a whole or gestalt. One of the characteristic ways in which biblical narratives inspire and teach is by (...) renewing their characters’ and readers’ imagination. The texts do so not inexorably but in a similar way as (other) works of art. This paper therefore investigates the ways in which works of art engage and develop the imagination, and thereby enable renewed perceptual and cognitive engagement with the world. The paper introduces predictive processing as a helpful psychological theory for analyzing this dynamic, and outlines questions for further research. (shrink)

a book review for Hagen Schulze's "Gibt es überhaupt eine deutsche Geschichte?" done as a homework for university (KIT Institut für Geschichte) Modul Pol.G. I.

Moral distress is the sense that one must do, or cooperate in, what is wrong. It is paradigmatically faced by nurses, but it is almost a universal occupational hazard.

Business Ethics and medical ethics are in principle compatible: In particular, the tools of business ethics can be useful to those doing healthcare ethics. Health care could be conducted as a business and maintain its moral core.

This paper has two aims. The first is to describe several sources of the moral responsibility to remedy or alleviate global poverty—reasons why an agent might have such a responsibility. The second is to consider what sorts of agents bear the responsibilities associated with each source—in particular, whether they are collective agents like states, societies, or corporations, on the one hand, or individual human beings on the other. We often talk about our responsibilities to the poorest people in the world, (...) or what we owe them. So the question is who this we is. I shall argue that the answer depends on the source of the responsibility. Some responsibilities—one species of causal responsibilities—belong in the first instance to collectives, although they will also trickle down to at least some individuals within the collective. Other responsibilities—humanitarian responsibilities, and a different species of causal responsibilities—belong in the first instance to individuals, but can, I shall argue, “trickle up” to collectives of which individuals are members. (shrink)

Elderhood—or old age, if one prefers—is a stage of life without much cultural meaning. It is generally viewed simply as a time of regrettable decline. Paying more attention to it, to its special pleasures and developmental achievements, will be helpful not only to elders but to those younger as well. I will argue that three existential tasks are central in elderhood, but also important at every other stage of adult life. I identify three: cherishing the present, accepting the past, and (...) investing in a future broader than one’s own. Articulating these tasks is intellectually interesting, useful to elders, and should be enlightening (as well as reassuring) to younger adults. (shrink)

Margaret Urban Walker argues that hospital ethics committees should think of their task as "keeping moral space open." I develop her suggestion with analogies: Enlarge the windows (i.e., expand what counts as an ethical issue); add rooms and doors (i.e., choose particular issues to engage). Examples include confidentiality defined as information flow, and moral distress in the healthcare workplace.

When people act to aid others, they get something in return—at the very least, the satisfaction of having their desire to help fulfilled. Some conclude from this and other puzzles about motivation that people always act simply to benefit themselves. But this is an error: there is altruism in the world, although it is often inextricably linked with the well-being of the agent who does good.

As feminist theory explicates its fundamental principles – justice for the oppressed – it can lose its essential focus on the situation of women. One example is the inattention to nurses within feminist bioethics. Nurses deserve attention because most are women, but also because their lack of power is paradigmatic of patriarchy. Those examining ethics consultations should discuss whether nurses are allowed to request them. But feminists also need to imagine ways in which nurses can be heard when, for instance, (...) their worklives are “redesigned.” Doing so would also allow attention to other classes of the disempowered. (shrink)

Klein, Nguyen, & Zhang (in press) argued that the evolutionary transition from respondent to agent during the Cambrian Explosion would be a promising vantage point from which to gain insight into the evolution of organic sentience. They focused on how increased competition for resources -- in consequence of the proliferation of new, neurally sophisticated life-forms -- made awareness of the external world (in the service of agentic acts) an adaptive priority. The explanatory scope of Klein et al (in press) was (...) limited to consideration of the conscious apprehension of externally sourced content – i.e., content delivered from the sensory registration of objects occupying phenomenal space. But consciousness – at least for humans -- takes its objects from internal as well as external sources. In the present article we extend their analysis to the question of how internally sourced content (i.e., mental states) became the object of conscious apprehension. (shrink)

It has been argued that some animals are moral subjects, that is, beings who are capable of behaving on the basis of moral motivations. In this paper, we do not challenge this claim. Instead, we presuppose its plausibility in order to explore what ethical consequences follow from it. Using the capabilities approach, we argue that beings who are moral subjects are entitled to enjoy positive opportunities for the flourishing of their moral capabilities, and that the thwarting of these capabilities entails (...) a harm that cannot be fully explained in terms of hedonistic welfare. We explore the implications of this idea for the assessment of current practices involving animals. (shrink)

Consciousness is targeted by both philosophers and neuroscientists; but different methodological premises and even different conceptions about what conscious experience is and how the challenges and potential problems associated with consciousness research should be formulated underlie the different approaches. Namely, whereas empirical data and the constant refinement of experimental procedures to expand and modify this body of empirical data and resulting empirical theories are crucial to neuroscience, the significance of empirical knowledge to philosophy is less clear: Although empirical data certainly (...) can influence philosophical concepts, the latter are nonetheless prerequisites of empirical research itself and thus may themselves not be empirically testable. The present paper elaborates from a multidisciplinary, neuroscientist-philosopher’s perspective the relation of philosophical concepts and empirical research on consciousness, drawing on two exemplary controversies from the philosophy of mind – on the ontological status of experiential properties and on free will. Consequences from both the scientific and the philosophical standpoint are discussed. (shrink)

León and Zahavi (2023) have made a compelling case for the necessity of philosophy — and not only neuroscience — for investigating consciousness. In particular, they argue that any theory of consciousness cannot avoid philosophical enquiry and thus only can choose between good or bad philosophy. Also, the topics of self-consciousness and selfhood are highlighted as problems of consciousness sui generis next to the mind–body problem. I will try to elucidate a bit more the specific approaches to consciousness that philosophy (...) and neuroscience take and thus elaborate why the philosophy and the neuroscience of consciousness are complimentary rather than mutually exclusive. (shrink)